est_a1b1
estimate shape parameters a1,b1est_a1b1.Rd
This function estimates shape parameters for a prior distribution of control allele frequencies
est_a1b1
estimate shape parameters a1,b1
est_a1b1(a0, b0, target.or, target.prob, nsim)
a0 | a scalar - beta distribution alpha shape parameter for prior on allele frequency in controls |
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b0 | a scalar - beta distribution beta shape parameter for prior on allele frequency in controls |
target.or | a scalar - an odds ratio threshold to compute P(sim.or > target.or) |
target.prob | a scalar - a probability that a sampled variant will exceed target.or |
nsim | a scalar - number of log odds ratios to simulate from the posterior distribution |
list - shape parameters for beta distribution satisfying target.or,target.prob and control prior distribution constraints.