fopt estimate the P(OR > target.or) given shape parameters for case and control allele frequencyfopt.RdThis function computes the optimal shape parameter a1 for a given set of constraints
shape parameters estimate the P(OR > target.or).
fopt estimate the P(OR > target.or) given shape parameters for case and control allele frequency
fopt(a1, target.prob, target.or, p, a0, b0)
| a1 | a scalar - beta distribution alpha shape parameter for prior on allele frequency in cases |
|---|---|
| target.prob | a scalar - a probability that a sampled variant will exceed target.or |
| target.or | a scalar - an odds ratio threshold to compute P(sim.or > target.or) |
| p | - a vector of values to optimise over |
| a0 | a scalar - beta distribution alpha shape parameter for prior on allele frequency in controls |
| b0 | a scalar - beta distribution beta shape parameter for prior on allele frequency in controls |
scalar - P(sim.or>target.or)