2017

  1. The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age. Inshaw J, Walker N, Wallace C, Bottolo L, Todd J.
    Diabetologia 2017 DOI
  2. Chromosome contacts in activated T cells identify autoimmune disease candidate genes Burren O, Rubio García A, Javierre B, Rainbow D, Cairns J, Cooper N, Lambourne J, Schofield E, Castro Dopico X, Ferreira R, Coulson R, Burden F, Rowlston S, Downes K, Wingett S, Frontini M, Ouwehand W, Fraser P, Spivakov M, Todd J, Wicker L, Cutler A, Wallace C.
    Genome Biology 2017 DOI PMC preprint
  3. Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity Ferreira R, Simons H, Thompson W, Rainbow D, Yang X, Cutler A, Oliveira J, Castro Dopico X, Smyth D, Savinykh N, Mashar M, Vyse T, Dunger D, Baxendale H, Chandra A, Wallace C, Todd J, Wicker L, Pekalski M.
    Journal of autoimmunity 2017 DOI PMC
  4. Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2 Pekalski M, García A, Ferreira R, Rainbow D, Smyth D, Mashar M, Brady J, Savinykh N, Dopico X, Mahmood S, Duley S, Stevens H, Walker N, Cutler A, Waldron-Lynch F, Dunger D, Shannon-Lowe C, Coles A, Jones J, Wallace C, Todd J, Wicker L.
    JCI insight 2017 DOI PMC
  5. A genetic test for differential causative pathology in disease subgroups Liley J, Todd J, Wallace C.
    Nat Genet 2017 DOI PMC preprint

2016

  1. Lineage-specific genome architecture links disease variants to target genes Javierre B, Burren O, Wilder S, Kreuzhuber R, Hill S, Sewitz S, Cairns J, Wingett S, Várnai C, Thiecke M, Burden F, Farrow S, Cutler A, Rehnstrom K, Downes K, Grassi L, Kostadima M, Freire-Pritchett P, Wang F, The BLUEPRINT Consortium , Stunnenberg H, Todd J, Zerbino D, Stegle O, Ouwehand W, *Frontini M , *Wallace C, *Spivakov M , *Fraser P .
    Cell 2016 DOI PMC
  2. Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial Todd J, Evangelou M, Cutler A, Pekalski M, Walker N, Stevens H, Porter L, Smyth D, Rainbow D, Ferreira R, Esposito L, Hunter K, Loudon K, Irons K, Yang J, Bell C, Schuilenburg H, Heywood J, Challis B, Neupane S, Clarke P, Coleman G, Dawson S, Goymer D, Anselmiova K, Kennet J, Brown J, Caddy S, Lu J, Greatorex J, Goodfellow I, Wallace C, Tree T, Evans M, Mander A, Bond S, Wicker L, Waldron-Lynch F.
    PLOS Medicine 2016 DOI

2015

  1. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Castro Dopico X, Evangelou M, Ferreira R, Guo H, Pekalski M, Smyth D, Ziegler A, Bonifacio E, *Wallace C, *Todd J.
    Nat Commun 2015 DOI PMC
  2. IL-21 production by CD4^+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients Ferreira R, Simons H, Thompson W, Cutler A, Dopico X, Smyth D, Mashar M, Schuilenburg H, Walker N, Dunger D, Wallace C, Todd J, Wicker L, Pekalski M.
    Diabetologia 2015 DOI PMC
  3. Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes Yang J, Cutler A, Ferreira R, Reading J, Cooper N, Wallace C, Clarke P, Smyth D, Boyce C, Gao G, Todd J, Wicker L, Tree T.
    Diabetes 2015 DOI PMC
  4. Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing Rainbow D, Yang X, Burren O, Pekalski M, Smyth D, Klarqvist M, Penkett C, Brugger K, Martin H, Todd J, Wallace C, Wicker L.
    European journal of immunology 2015 DOI PMC
  5. Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases. Guo H, Fortune M, Burren O, Schofield E, Todd J, Wallace C.
    Hum Mol Genet 2015 DOI PMC
  6. Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping. Wallace C, Cutler A, Pontikos N, Pekalski M, Burren O, Cooper J, García A, Ferreira R, Guo H, Walker N, Smyth D, Rich S, Onengut-Gumuscu S, Sawcer S, Ban M, Richardson S, Todd J, Wicker L.
    PLoS Genet 2015 DOI PMC
  7. Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis. Bowes J, Budu-Aggrey A, Huffmeier U, Uebe S, Steel K, Hebert H, Wallace C, Massey J, Bruce I, Bluett J, Feletar M, Morgan A, Marzo-Ortega H, Donohoe G, Morris D, Helliwell P, Ryan A, Kane D, Warren R, Korendowych E, Alenius G, Giardina E, Packham J, McManus R, FitzGerald O, McHugh N, Brown M, Ho P, Behrens F, Burkhardt H, Reis A, Barton A.
    Nat Commun 2015 DOI PMC
  8. Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. Fortune M, Guo H, Burren O, Schofield E, Walker N, Ban M, Sawcer S, Bowes J, Worthington J, Barton A, Eyre S, Todd J, Wallace C.
    Nat Genet 2015 DOI PMC
  9. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Onengut-Gumuscu S, Chen W, Burren O, Cooper N, Quinlan A, Mychaleckyj J, Farber E, Bonnie J, Szpak M, Schofield E, Achuthan P, Guo H, Fortune M, Stevens H, Walker N, Ward L, Kundaje A, Kellis M, Daly M, Barrett J, Cooper J, Deloukas P, Type 1 Diabetes Genetics Consortium , *Todd J, *Wallace C, *Concannon P, *Rich S.
    Nat Genet 2015 DOI PMC
  10. A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics Liley J, Wallace C.
    PLoS Genet 2015 DOI PMC

2014

  1. VSEAMS: a pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes. Burren O, Guo H, Wallace C.
    Bioinformatics 2014 DOI PMC preprint
  2. A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples. Pontikos N, Smyth D, Schuilenburg H, Howson J, Walker N, Burren O, Guo H, Onengut-Gumuscu S, Chen W, Concannon P, Rich S, Jayaraman J, Jiang W, Traherne J, Trowsdale J, Todd J, Wallace C.
    BMC Genomics 2014 DOI PMC
  3. Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes. Thompson W, Pekalski M, Simons H, Smyth D, Castro-Dopico X, Guo H, Guy C, Dunger D, Arif S, Peakman M, Wallace C, Wicker L, Todd J, Ferreira R.
    Clin Exp Immunol 2014 DOI PMC
  4. A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes. Ferreira R, Guo H, Coulson R, Smyth D, Pekalski M, Burren O, Cutler A, Doecke J, Flint S, McKinney E, Lyons P, Smith K, Achenbach P, Beyerlein A, Dunger D, Wicker L, *Todd J , *Bonifacio E , *Wallace C, *Ziegler G .
    Diabetes 2014 DOI PMC
  5. Plasma concentrations of soluble IL-2 receptor (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients. Downes K, Marcovecchio M, Clarke P, Cooper J, Ferreira R, Howson J, Jolley J, Nutland S, Stevens H, Walker N, Wallace C, Dunger D, Todd J.
    Diabetologia 2014 DOI PMC
  6. A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations. Evangelou M, Smyth D, Fortune M, Burren O, Walker N, Guo H, Onengut-Gumuscu S, Chen W, Concannon P, Rich S, Todd J, Wallace C.
    Genet Epidemiol 2014 DOI PMC
  7. Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics. Giambartolomei C, Vukcevic D, Schadt E, Franke L, Hingorani A, Wallace C, Plagnol V.
    PLoS Genet 2014 DOI PMC preprint
  8. A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes. Zanda M, Onengut-Gumuscu S, Walker N, Shtir C, Gallo D, Wallace C, Smyth D, Todd J, Hurles M, Plagnol V, Rich S.
    PLoS Genet 2014 DOI PMC
  9. Improved imputation quality of low-frequency and rare variants in European samples using the ’Genome of The Netherlands’. Deelen P, Menelaou A, van Leeuwen E, Kanterakis A, van Dijk F, Medina-Gomez C, Francioli L, Hottenga J, Karssen L, Estrada K, Kreiner-Møller E, Rivadeneira F, van Setten J, Gutierrez-Achury J, Westra H, Franke L, van Enckevort D, Dijkstra M, Byelas H, van Duijn C, Genome of the Netherlands Consortium , de Bakker P, Wijmenga C, Swertz M, Genome of the Netherlands Consortium .
    Eur J Hum Genet 2014 DOI

2013

  1. Statistical testing of shared genetic control for potentially related traits. Wallace C.
    Genet Epidemiol 2013 DOI PMC preprint
  2. Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors. Pekalski M, Ferreira R, Coulson R, Cutler A, Guo H, Smyth D, Downes K, Dendrou C, Castro Dopico X, Esposito L, Coleman G, Stevens H, Nutland S, Walker N, Guy C, Dunger D, Wallace C, Tree T, Todd J, Wicker L.
    J Immunol 2013 DOI PMC

2012

  1. Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Angelakopoulou A, Shah T, Sofat R, Shah S, Berry D, Cooper J, Palmen J, Tzoulaki I, Wong A, Jefferis B, Maniatis N, Drenos F, Gigante B, Hardy R, Laxton R, Leander K, Motterle A, Simpson I, Smeeth L, Thomson A, Verzilli C, Kuh D, Ireland H, Deanfield J, Caulfield M, Wallace C, Samani N, Munroe P, Lathrop M, Fowkes F, Marmot M, Whincup P, Whittaker J, Faire U, Kivimaki M, Kumari M, Hypponen E, Power C, Humphries S, Talmud P, Price J, Morris R, Ye S, Casas J, Hingorani A.
    Eur Heart J 2012 DOI PMC
  2. Extra-binomial variation approach for analysis of pooled DNA sequencing data. Yang X, Todd J, Clayton D, Wallace C.
    Bioinformatics 2012 DOI PMC
  3. Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Wallace C, Rotival M, Cooper J, Rice C, Yang J, McNeill M, Smyth D, Niblett D, Cambien F, Cardiogenics Consortium , Tiret L, Todd J, Clayton D, Blankenberg S.
    Hum Mol Genet 2012 DOI PMC
  4. Seven newly identified loci for autoimmune thyroid disease. Cooper J, Simmonds M, Walker N, Burren O, Brand O, Guo H, Wallace C, Stevens H, Coleman G, Wellcome Trust Case Control Consortium , Franklyn J, Todd J, Gough S.
    Hum Mol Genet 2012 DOI PMC
  5. Long-range DNA looping and gene expression analyses identify \emphDEXI as an autoimmune disease candidate gene. Davison, L , Wallace C, Cooper J, Cope N, Wilson N, Smyth D, Howson J, Saleh N, Al-Jeffery A, Angus K, Stevens H, Nutland S, Duley S, Coulson R, Walker N, Burren O, Rice C, Cambien F, Zeller T, Munzel T, Lackner K, Blankenberg S, Cardiogenics Consortium , Fraser P, Gottgens B, Todd J.
    Hum Mol Genet 2012 DOI PMC

2011

  1. Pervasive sharing of genetic effects in autoimmune disease. Cotsapas C, Voight B, Rossin E, Lage K, Neale B, Wallace C, Abecasis G, Barrett J, Behrens T, Cho J, Jager P, Elder J, Graham R, Gregersen P, Klareskog L, Siminovitch K, Heel D, Wijmenga C, Worthington J, Todd J, Hafler D, Rich S, Daly M, Consortia F.
    PLoS Genet 2011 PMC
  2. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Cooper J, Smyth D, Walker N, Stevens H, Burren O, Wallace C, Greissl C, Ramos-Lopez E, HyppÃnen E, Dunger D, Spector T, Ouwehand W, Wang T, Badenhoop K, Todd J.
    Diabetes 2011 DOI PMC
  3. Blood pressure loci identified with a gene-centric array Johnson T, Gaunt T, Newhouse S, Padmanabhan S, Tomaszewski M, Kumari M, Morris R, Tzoulaki I, O’Brien E, Poulter N, Sever P, Shields D, Thom S, Wannamethee S, Whincup P, Brown M, Connell J, Dobson R, Howard P, Mein C, Onipinla A, Shaw-Hawkins S, Zhang Y, Smith G, Day I, Lawlor D, Goodall A, Fowkes F, Abecasis G, Elliott P, Gateva V, Braund P, Burton P, Nelson C, Tobin M, Van Der Harst P, Glorioso N, Neuvrith H, Salvi E, Staessen J, Stucchi A, Devos N, Jeunemaitre X, Plouin P, Tichet J, Juhanson P, Org E, Putku M, Sauber S, Veldre G, Viigimaa M, Levinsson A, Rosengren A, Thelle D, Hastie C, Hedner T, Lee W, Melander O, Wahlstrand B, Hardy R, Wong A, Cooper J, Palmen J, Chen L, Stewart A, Wells G, Westra H, Wolfs M, Clarke R, Franzosi M, Goel A, Hamsten A, Lathrop M, Peden J, Seedorf U, Watkins H, Ouwehand W, Sambrook J, Stephens J, Casas J, Drenos F, Holmes M, Kivimaki M, Shah S, Shah T, Talmud P, Whittaker J, Wallace C, Delles C, Laan M, Kuh D, Humphries S, Nyberg F, Cusi D, Roberts R, Newton-Cheh C, Franke L, Stanton A, Dominiczak A, Farrall M, Hingorani A, Samani N, Caulfield M, Munroe P.
    American Journal of Human Genetics 2011 PMC
  4. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 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Waterworth D, Zerres K, Waeber G, Wareham N, Maxwell P, McCarthy M, Jarvelin M, Mooser V, Abecasis G, Lightstone L, Scott J, Navis G, Elliott P, Kooner J.
    Nature 2011 DOI
  5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Chambers J, Zhang W, Sehmi J, Li X, Wass M, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister S, Coin L, Deng G, Gieger C, Heard-Costa N, Hottenga J, Kühnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal P, Mateo Leach I, O’Reilly P, Peden J, Rahmioglu N, Soininen P, Speliotes E, Yuan X, Thorleifsson G, Alizadeh B, Atwood L, Borecki I, Brown M, Charoen P, Cucca F, Das D, de Geus E, Dixon A, Döring A, Ehret G, Eyjolfsson G, Farrall M, Forouhi N, Friedrich N, Goessling W, Gudbjartsson D, Harris T, Hartikainen A, Heath S, Hirschfield G, Hofman A, Homuth G, Hyppönen E, Janssen H, Johnson T, Kangas A, Kema I, Kühn J, Lai S, Lathrop M, Lerch M, Li Y, Liang T, Lin J, Loos R, Martin N, Moffatt M, Montgomery G, Munroe P, Musunuru K, Nakamura Y, O’Donnell C, Olafsson I, Penninx B, Pouta A, Prins B, Prokopenko I, Puls R, Ruokonen A, Savolainen M, Schlessinger D, Schouten J, Seedorf U, Sen-Chowdhry S, Siminovitch K, Smit J, Spector T, Tan W, Teslovich T, Tukiainen T, Uitterlinden A, Van der Klauw M, Vasan R, Wallace C, Wallaschofski H, Wichmann H, Willemsen G, Würtz P, Xu C, Yerges-Armstrong L, Alcohol Genome-wide Association (AlcGen) Consortium , Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study , Genetic Investigation of Anthropometric Traits (G. I. A. N. T) Consortium , Global Lipids Genetics Consortium and , Genetics of Liver Disease (G. O. L. D) Consortium , International Consortium for Blood Pressure (I. C. B. P-G. W. A. S) , Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) , Abecasis G, Ahmadi K, Boomsma D, Caulfield M, Cookson W, van Duijn C, Froguel P, Matsuda K, McCarthy M, Meisinger C, Mooser V, Pietiläinen K, Schumann G, Snieder H, Sternberg M, Stolk R, Thomas H, Thorsteinsdottir U, Uda M, Waeber G, Wareham N, Waterworth D, Watkins H, Whitfield J, Witteman J, Wolffenbuttel B, Fox C, Ala-Korpela M, Stefansson K, Vollenweider P, Völzke H, Schadt E, Scott J, Järvelin M, Elliott P, Kooner J.
    Nat Genet 2011 DOI
  6. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. Plagnol V, Howson J, Smyth D, Walker N, Hafler J, Wallace C, Stevens H, Jackson L, Simmonds M, Consortium T, Bingley P, Gough S, Todd J.
    PLoS Genet 2011 DOI PMC
  7. Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes. Saleh N, Raj S, Smyth D, Wallace C, Howson J, Bell L, Walker N, Stevens H, Todd J.
    Diabetes Metab Res Rev 2011 DOI
  8. An allele of \emphIKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes. Swafford A, Howson J, Davison L, Wallace C, Smyth D, Schuilenburg H, Maisuria-Armer M, Mistry T, Lenardo M, Todd J.
    Diabetes 2011 DOI PMC
  9. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Trynka G, Hunt K, Bockett N, Romanos J, Mistry V, Szperl A, Bakker S, Bardella M, Bhaw-Rosun L, Castillejo G, de la Concha E, de Almeida R, Dias K, van Diemen C, Dubois P, Duerr R, Edkins S, Franke L, Fransen K, Gutierrez J, Heap G, Hrdlickova B, Hunt S, Izurieta L, Izzo V, Joosten L, Langford C, Mazzilli M, Mein C, Midah V, Mitrovic M, Mora B, Morelli M, Nutland S, Núñez C, Onengut-Gumuscu S, Pearce K, Platteel M, Polanco I, Potter S, Ribes-Koninckx C, Ricaño-Ponce I, Rich S, Rybak A, Santiago J, Senapati S, Sood A, Szajewska H, Troncone R, Varadé J, Wallace C, Wolters V, Zhernakova A, Spanish Consortium on the Genetics of Coeliac Disease (C. E. G. E. C) , Prevent C. D Study Group , Wellcome Trust Case Control Consortium (W. T. C. C. C) , Thelma B, Cukrowska B, Urcelay E, Bilbao J, Mearin M, Barisani D, Barrett J, Plagnol V, Deloukas P, Wijmenga C, van Heel D.
    Nat Genet 2011 DOI

2010

  1. Reduced expression of \emphIFIH1 is protective for type 1 diabetes. Downes K, Pekalski M, Angus K, Hardy M, Nutland S, Smyth D, Walker N, Wallace C, Todd J.
    PLoS One 2010 DOI PMC
  2. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Heinig M , Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley S, Bauerfeind A, Hummel O, Lee Y, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray E, Cyster J, Consortium C, Erdmann J, Hengstenberg C, Maouche S, Ouwehand W, Rice C, Samani N, Schunkert H, Goodall A, Schulz H, Roider H, Vingron M, Blankenberg S, Maenzel T, Zeller T, Szymczak S, Ziegler A, Tiret L, Smyth D, Pravenec M, Aitman T, Cambien F, Clayton D, Todd J, Hubner N, Cook S.
    Nature 2010 DOI PMC
  3. Genetic loci influencing kidney function and chronic kidney disease. Chambers J, Zhang W, Lord G, van der Harst P, Lawlor D, Sehmi J, Gale D, Wass M, Ahmadi K, Bakker S, Beckmann J, Bilo H, Bochud M, Brown M, Caulfield M, Connell J, Cook H, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei L, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Ferrucci L, Floege J, Forouhi N, Gansevoort R, Han X, Hedblad B, Homan van der Heide J, Hepkema B, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong P, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos R, Luan J, Luttropp K, Maréchal C, Melander O, Munroe P, Nordfors L, Parsa A, Peltonen L, Penninx B, Perucha E, Pouta A, Prokopenko I, Roderick P, Ruokonen A, Samani N, Sanna S, Schalling M, Schlessinger D, Schlieper G, Seelen M, Shuldiner A, Sjögren M, Smit J, Snieder H, Soranzo N, Spector T, Stenvinkel P, Sternberg M, Swaminathan R, Tanaka T, Ubink-Veltmaat L, Uda M, Vollenweider P, Wallace C, Waterworth D, Zerres K, Waeber G, Wareham N, Maxwell P, McCarthy M, Jarvelin M, Mooser V, Abecasis G, Lightstone L, Scott J, Navis G, Elliott P, Kooner J.
    Nat Genet 2010 DOI
  4. The imprinted \emphDLK1-\emphMEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Wallace C, Smyth D, Maisuria-Armer M, Walker N, Todd J, Clayton D.
    Nat Genet 2010 DOI PMC
  5. A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor. Chung C, Wang R, Chen J, Fann C, Leu H, Ho H, Ting C, Lin T, Sheu S, Tsai W, Chen J, Jong Y, Lin S, Chen Y, Pan W.
    Pharmacogenomics J 2010 DOI
  6. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Wellcome Trust Case Control Consortium , Craddock N, Hurles M, Cardin N, Pearson R, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad D, Giannoulatou E, Holmes C, Marchini J, Stirrups K, Tobin M, Wain L, Yau C, Aerts J, Ahmad T, Andrews T, Arbury H, Attwood A, Auton A, Ball S, Balmforth A, Barrett J, Barroso I, Barton A, Bennett A, Bhaskar S, Blaszczyk K, Bowes J, Brand O, Braund P, Bredin F, Breen G, Brown M, Bruce I, Bull J, Burren O, Burton J, Byrnes J, Caesar S, Clee C, Coffey A, Connell J, Cooper J, Dominiczak A, Downes K, Drummond H, Dudakia D, Dunham A, Ebbs B, Eccles D, Edkins S, Edwards C, Elliot A, Emery P, Evans D, Evans G, Eyre S, Farmer A, Ferrier I, Feuk L, Fitzgerald T, Flynn E, Forbes A, Forty L, Franklyn J, Freathy R, Gibbs P, Gilbert P, Gokumen O, Gordon-Smith K, Gray E, Green E, Groves C, Grozeva D, Gwilliam R, Hall A, Hammond N, Hardy M, Harrison P, Hassanali N, Hebaishi H, Hines S, Hinks A, Hitman G, Hocking L, Howard E, Howard P, Howson J, Hughes D, Hunt S, Isaacs J, Jain M, Jewell D, Johnson T, Jolley J, Jones I, Jones L, Kirov G, Langford C, Lango-Allen H, Lathrop G, Lee J, Lee K, Lees C, Lewis K, Lindgren C, Maisuria-Armer M, Maller J, Mansfield J, Martin P, Massey D, McArdle W, McGuffin P, McLay K, Mentzer A, Mimmack M, Morgan A, Morris A, Mowat C, Myers S, Newman W, Nimmo E, O’Donovan M, Onipinla A, Onyiah I, Ovington N, Owen M, Palin K, Parnell K, Pernet D, Perry J, Phillips A, Pinto D, Prescott N, Prokopenko I, Quail M, Rafelt S, Rayner N, Redon R, Reid D, Renwick , Ring S, Robertson N, Russell E, Clair D, Sambrook J, Sanderson J, Schuilenburg H, Scott C, Scott R, Seal S, Shaw-Hawkins S, Shields B, Simmonds M, Smyth D, Somaskantharajah E, Spanova K, Steer S, Stephens J, Stevens H, Stone M, Su Z, Symmons D, Thompson J, Thomson W, Travers M, Turnbull C, Valsesia A, Walker M, Walker N, Wallace C, Warren-Perry M, Watkins N, Webster J, Weedon M, Wilson A, Woodburn M, Wordsworth B, Young A, Zeggini E, Carter N, Frayling T, Lee C, McVean G, Munroe P, Palotie A, Sawcer S, Scherer S, Strachan D, Tyler-Smith C, Brown M, Burton P, Caulfield M, Compston A, Farrall M, Gough S, Hall A, Hattersley A, Hill A, Mathew C, Pembrey M, Satsangi J, Stratton M, Worthington J, Deloukas P, Duncanson A, Kwiatkowski D, McCarthy M, Ouwehand W, Parkes M, Rahman N, Todd J, Samani N, Donnelly P.
    Nature 2010 DOI PMC

2009

  1. Genome-wide association study identifies eight loci associated with blood pressure. Newton-Cheh C, Johnson T, Gateva V, Tobin M, Bochud M, Coin L, Najjar S, Zhao J, Heath S, Eyheramendy S, Papadakis K, Voight B, Scott L, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers J, Khaw K, Nilsson P, van der Harst P, Polidoro S, Grobbee D, Onland-Moret N, Bots M, Wain L, Elliott K, Teumer A, Luan J, Lucas G, Kuusisto J, Burton P, Hadley D, McArdle W, Wellcome Trust Case Control Consortium , Brown M, Dominiczak A, Newhouse S, Samani N, Webster J, Zeggini E, Beckmann J, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth D, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu M, Luben R, Crawford G, Jousilahti P, Perola M, Boehnke M, Bonnycastle L, Collins F, Jackson A, Mohlke K, Stringham H, Valle T, Willer C, Bergman R, Morken M, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann H, Kathiresan S, Marrugat J, O’Donnell C, Schwartz S, Siscovick D, Subirana I, Freimer N, Hartikainen A, McCarthy M, O’Reilly P, Peltonen L, Pouta A, de Jong P, Snieder H, van Gilst W, Clarke R, Goel A, Hamsten A, Peden J, Seedorf U, Syvänen A, Tognoni G, Lakatta E, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix S, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut I, Hercberg S, Lathrop G, Zelenika D, Deloukas P, Soranzo N, Williams F, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi N, Völzke H, Uiterwaal C, van der Schouw Y, Numans M, Matullo G, Navis G, Berglund G, Bingham S, Kooner J, Connell J, Bandinelli S, Ferrucci L, Watkins H, Spector T, Tuomilehto J, Altshuler D, Strachan D, Laan M, Meneton P, Wareham N, Uda M, Jarvelin M, Mooser V, Melander O, Loos R, Elliott P, Abecasis G, Caulfield M, Munroe P.
    Nat Genet 2009 DOI
  2. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Willer C, Speliotes E, Loos R, Li S, Lindgren C, Heid I, Berndt S, Elliott A, Jackson A, Lamina C, Lettre G, Lim N, Lyon H, McCarroll S, Papadakis K, Qi L, Randall J, Roccasecca R, Sanna S, Scheet P, Weedon M, Wheeler E, Zhao J, Jacobs L, Prokopenko I, Soranzo N, Tanaka T, Timpson N, Almgren P, Bennett A, Bergman R, Bingham S, Bonnycastle L, Brown M, Burtt N, Chines P, Coin L, Collins F, Connell J, Cooper C, Smith G, Dennison E, Deodhar P, Elliott P, Erdos M, Estrada K, Evans D, Gianniny L, Gieger C, Gillson C, Guiducci C, Hackett R, Hadley D, Hall A, Havulinna A, Hebebrand J, Hofman A, Isomaa B, Jacobs K, Johnson T, Jousilahti P, Jovanovic Z, Khaw K, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta E, Luan J, Luben R, Mangino M, McArdle W, Meitinger T, Mulas A, Munroe P, Narisu N, Ness A, Northstone K, O’Rahilly S, Purmann C, Rees M, Ridderstrale M, Ring S, Rivadeneira F, Ruokonen A, Sandhu M, Saramies J, Scott L, Scuteri A, Silander K, Sims M, Song K, Stephens J, Stevens S, Stringham H, Tung Y, Valle T, Duijn C, Vimaleswaran K, Vollenweider P, Waeber G, Wallace C, Watanabe R, Waterworth D, Watkins N, Wellcome Trust Case Control Consortium , Witteman J, Zeggini E, Zhai G, Zillikens M, Altshuler D, Caulfield M, Chanock S, Farooqi I, Ferrucci L, Guralnik J, Hattersley A, Hu F, Jarvelin M, Laakso M, Mooser V, Ong K, Ouwehand W, Salomaa V, Samani N, Spector T, Tuomi T, Tuomilehto J, Uda M, Uitterlinden A, Wareham N, Deloukas P, Frayling T, Groop L, Hayes R, Hunter D, Mohlke K, Peltonen L, Schlessinger D, Strachan D, Wichmann H, McCarthy M, Boehnke M, Barroso I, Abecasis G, Hirschhorn J, Genetic Investigation of Anthropometric Traits Consortium .
    Nat Genet 2009
  3. Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt D, Aulchenko Y, Beckmann J, Bergmann S, Bochud M, Brown M, Campbell H, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy M, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani N, Schlessinger D, Uda M, Valker U, Waeber G, Waterworth D, Wang-Sattler R, Wright A, Adamski J, Whitfield J, Gyllensten U, Wilson J, Rudan I, Pramstaller P, Watkins H, Doering A, Wichmann H, Spector T, Peltonen L, Valzke H, Nagaraja R, Vollenweider P, Caulfield M, Illig T, Gieger C, EUROSPAN Consortium , ENGAGE Consortium , PROCARDIS Consortium , KORA Study , WTCCC .
    PLoS Genet 2009 DOI
  4. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. Lindgren C, Heid I, Randall J, Lamina C, Steinthorsdottir V, Qi L, Speliotes E, Thorleifsson G, Willer C, Herrera B, Jackson A, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko Y, Chambers J, Drong A, Luan J, Lyon H, Rivadeneira F, Sanna S, Timpson N, Zillikens M, Zhao J, Almgren P, Bandinelli S, Bennett A, Bergman R, Bonnycastle L, Bumpstead S, Chanock S, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney A, Ebrahim S, Elliott P, Erdos M, Estrada K, Ferrucci L, Fischer G, Forouhi N, Gieger C, Grallert H, Groves C, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna A, Hofman A, Holle R, Holloway J, Illig T, Isomaa B, Jacobs L, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop G, Lawlor D, Mangino M, McArdle W, Meitinger T, Morken M, Morris A, Munroe P, Narisu N, NordstrÃm A, NordstrÃm P, Oostra B, Palmer C, Payne F, Peden J, Prokopenko I, RenstrÃm F, Ruokonen A, Salomaa V, Sandhu M, Scott L, Scuteri A, Silander K, Song K, Yuan X, Stringham H, Swift A, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters G, Weedon M, WTCCC , Witteman J, Zhang C, Zhang W, Caulfield M, Collins F, Smith G, Day I, Franks P, Hattersley A, Hu F, Jarvelin M, Kong A, Kooner J, Laakso M, Lakatta E, Mooser V, Morris A, Peltonen L, Samani N, Spector T, Strachan D, Tanaka T, Tuomilehto J, Uitterlinden A, Duijn C, Wareham N, Watkins H, Procardis Consortia , Waterworth D, Boehnke M, Deloukas P, Groop L, Hunter D, Thorsteinsdottir U, Schlessinger D, Wichmann H, Frayling T, Abecasis G, Hirschhorn J, Loos R, Stefansson K, Mohlke K, Barroso I, McCarthy M, Giant Consortium .
    PLoS Genet 2009 DOI
  5. Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K, Shaw-Hawkins S, Dobson R, Brown M, Samani N, Dominiczak A, Connell J, Lathrop G, Kooner J, Chambers J, Elliott P, Clarke R, Collins R, Laan M, Org E, Juhanson P, Veldre G, Viigimaa M, Eyheramendy S, Cappuccio F, Ji C, Iacone R, Strazzullo P, Kumari M, Marmot M, Brunner E, Caulfield M, Munroe P.
    PLoS ONE 2009 DOI
  6. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. Nolte I, Wallace C, Newhouse S, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P, Savelieva I, Zheng D, Dalageorgou C, Farrall M, Samani N, Connell J, Brown M, Dominiczak A, Lathrop M, Zeggini E, Wain L, WTCCC , DCCT/EDIC Research Group , Newton-Cheh C, Eijgelsheim M, Rice K, Bakker P, QTGEN consortium , Pfeufer A, Sanna S, Arking D, QTSCD consortium , Asselbergs F, Spector T, Carter N, Jeffery S, Tobin M, Caulfield M, Snieder H, Paterson A, Munroe P, Jamshidi Y.
    PLoS One 2009 DOI

2008

  1. Genome-wide association study identifies novel genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia Wallace C, Newhouse S, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson R, Marçano A, Hajat C, Burton P, Deloukas P, Brown M, Connell J, Dominiczak A, Lathrop G, Webster J, The Wellcome Trust Case Control Consortium , Farrall M, Spector T, Samani N, Caulfield M, Munroe P.
    Am J Hum Genet 2008 DOI
  2. Glutathione S-transferase variants and hypertension. Delles C, Padmanabhan S, Lee W, Miller W, McBride M, McClure J, Brain N, Wallace C, Marçano A, Schmieder R, Brown M, Caulfield M, Munroe P, Farrall M, Webster J, Connell J, Dominiczak A.
    J Hypertens 2008 DOI
  3. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Loos R, Lindgren C, Li S, Wheeler E, Zhao J, Prokopenko I, Inouye M, Freathy R, Attwood A, Beckmann J, Berndt S, Prostate, LungColorectal, and Ovarian (PLCO) Cancer Screening Trial , Jacobs K, Chanock S, Hayes R, Bergmann S, Bennett A, Bingham S, Bochud M, Brown M, Cauchi S, Connell J, Cooper C, Smith G, Day I, Dina C, De S, Dermitzakis E, Doney A, Elliott K, Elliott P, Evans D, Farooqi I, Froguel P, Ghori J, Groves C, Gwilliam R, Hadley D, Hall A, Hattersley A, Hebebrand J, Heid I, K.O.R.A. , Lamina C, Gieger C, Illig T, Meitinger T, Wichmann H, Herrera B, Hinney A, Hunt S, Jarvelin M, Johnson T, Jolley J, Karpe F, Keniry A, Khaw K, Luben R, Mangino M, Marchini J, McArdle W, McGinnis R, Meyre D, Munroe P, Morris A, Ness A, Neville M, Nica A, Ong K, O’Rahilly S, Owen K, Palmer C, Papadakis K, Potter S, Pouta A, Qi L, Nurses’ Health Study , Randall J, Rayner N, Ring S, Sandhu M, Scherag A, Sims M, Song K, Soranzo N, Speliotes E, Initiative D, Syddall H, Teichmann S, Timpson N, Tobias J, Uda M, Study S, Vogel C, Wallace C, Waterworth D, Weedon M, Wellcome Trust Case Control Consortium , Willer C, F.U.S.I.O.N. , Wraight , Yuan X, Zeggini E, Hirschhorn J, Strachan D, Ouwehand W, Caulfield M, Samani N, Frayling T, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy M, Wareham N, Barroso I, Jacobs K, Chanock S, Hayes R, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann H, Kraft P, Hankinson S, Hunter D, Hu F, Lyon H, Voight B, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis G, Albai G, Nagaraja R, Schlessinger D, Jackson A, Tuomilehto J, Collins F, Boehnke M, Mohlke K.
    Nat Genet 2008 DOI
  4. Genome-wide association analysis identifies 20 loci that influence adult height. Weedon M, Lango H, Lindgren C, Wallace C, Evans D, Mangino M, Freathy R, Perry J, Stevens S, AS H, Samani N, Shields B, Prokopenko I, Farrall M, Dominiczak A, Diabetes Genetics Initiative , Wellcome Trust Case Control Consortium , Johnson T, Bergmann S, Beckmann J, Vollenweider P, Waterworth D, Mooser V, Palmer C, Morris A, Ouwehand W, Cambridge GEM Consortium , Zhao J, Li S, Loos R, Barroso I, Deloukas P, Sandhu M, Wheeler E, Soranzo N, Inouye M, Wareham N, Caulfield M, Munroe P, Hattersley A, McCarthy M, Frayling T.
    Nat Genet 2008 DOI
  5. Extreme Clonality in Lymphoblastoid Cell Lines with Implications for Allele Specific Expression Analyses Plagnol V, Uz E, Wallace C, Stevens H, Clayton D, Ozcelik T, Todd J.
    PLoS ONE 2008 DOI
  6. SLC2A9 Is a High-Capacity Urate Transporter in Humans. Caulfield M, Munroe P, O’Neill D, Witkowska K, Charchar F, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson R, Wallace C, Newhouse S, Brown M, Connell J, Dominiczak A, Farrall M, Lathrop G, Samani N, Kumari M, Marmot M, Brunner E, Chambers J, Elliott P, Kooner J, Laan M, Org E, Veldre G, Viigimaa M, Cappuccio F, Ji C, Iacone R, Strazzullo P, Moley K, Cheeseman C.
    PLoS Med 2008 DOI

2007

  1. Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates. Wallace C, Dobson R, Munroe P, Caulfield M.
    Genome Res 2007 DOI
  2. Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. Marçano A, Burke B, Gungadoo J, Wallace C, Kaisaki P, Woon P, Farrall M, Clayton D, Brown M, Dominiczak A, Connell J, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D, Munroe P.
    J Med Genet 2007 DOI
  3. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Todd J, Walker N, Cooper J, Smyth D, Downes K, Plagnol V, Bailey R, Nejentsev S, Field S, Payne F, Lowe C, Szeszko J, Hafler J, Zeitels L, Yang J, Vella A, Nutland S, Stevens H, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink L, Healy B, Burren O, Lam A, Ovington N, Allen J, Adlem E, Leung H, Wallace C, Howson J, Guja C, Ionescu-Tîrgoviste C, Finland G, Simmonds M, Heward J, Gough S, Dunger D, Wellcome Trust Case Control Consortium , Wicker L, Clayton D.
    Nat Genet 2007 DOI
  4. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Wellcome Trust Case Control Consortium .
    Nature 2007

2006

  1. Appropriate use of information on family history of disease in recruitment for linkage analysis studies Wallace C, Clayton D.
    Ann Hum Genet 2006 DOI
  2. Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping. Wallace C, Chapman J, Clayton D.
    Am J Hum Genet 2006 DOI
  3. Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension Wallace C, Xue M, Newhouse S, Marçano A, Onipinla A, Burke B, Gungadoo J, Dobson R, Brown M, Connell J, Dominiczak A, Lathrop G, Webster J, Farrall M, Mein C, Samani N, Caulfield M, Clayton D, Munroe P.
    Am J Hum Genet 2006
  4. Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study. Munroe P, Wallace C, Xue M, Marçano A, Dobson R, Onipinla A, Burke B, Gungadoo J, Newhouse S, Pembroke J, Brown M, Dominiczak A, Samani N, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein C, Caulfield M, Medical Research Council British Genetics of Hypertension Study .
    Hypertension 2006
  5. Two-dimensional genome scan identifies novel epistatic loci for essential hypertension. Bell J, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop G, Connell J, Munroe P, Caulfield M, Farrall M.
    Hum Mol Genet 2006 DOI
  6. Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. Binder A, Garcia E, Wallace C, Gbenga K, Ben-Shlomo Y, Yarnell J, Brown P, Caulfield M, Skrabal F, Kotanko P, Munroe P.
    J Hypertens 2006 DOI
  7. Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the BRItish Genetics of HyperTension Study. Padmanabhan S, Wallace C, Munroe P, Dobson R, Brown M, Samani N, Clayton D, Farrall M, Webster J, Lathrop M, Caulfield M, Dominiczak A, Connell J.
    Hypertension 2006 DOI

2005

  1. Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Newhouse S, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell J, Webster J, Lathrop G, Caulfield M, Munroe P.
    Hum Mol Genet 2005 DOI

2004

  1. Linkage analysis of susceptibility to leprosy type using an IBD regression method. Wallace C, Fitness J, Hennig B, Sichali L, Mwaungulu L, Pönnighaus J, Warndorff D, Clayton D, Fine P, Hill A.
    Genes Immun 2004 DOI

2003

  1. Trends in drug overdose deaths in England and Wales 1993-98: methadone does not kill more people than heroin. Hickman M, Madden P, Henry J, Baker A, Wallace C, Wakefield J, Stimson G, Elliott P.
    Addiction 2003
  2. Estimating the relative recurrence risk ratio using a global cross-ratio model. Wallace C, Clayton D.
    Genet Epidemiol 2003 DOI
  3. Estimating the relative recurrence risk ratio for leprosy in Karonga District, Malawi. Wallace C, Clayton D, Fine P.
    Lepr Rev 2003

2001

  1. Measuring differences in the provision of diabetes care New J, Roxburgh M, Vaughan N, Wallace C, Elliott P, Young R.
    Diabetes Nutrition & Metabolism 2001